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Emergency services were called to a two vehicle collision on the A38 last night, Saturday 11 November.
The incident, which took place at the junction of the B412 and Highfield Business Park, occurred at around 8.30pm.
It involved a grey Nissan Qashqai and a black Ford Focus.
Four people in the Focus and two in the Qashqai were taken to Gloucestershire Royal Hospital for treatment of suspected broken bones and cuts and bruising.
The road was closed for six hours but has now reopened.
The driver of the Qashqai, a 30-year-old man from Tewkesbury, was discharged and subsequently arrested on suspicion of driving while over the legal limit for alcohol and causing serious injury by dangerous driving. He remains in police custody at this time.
Officers are appealing for anyone who witnessed the collision or who has dashcam footage of the vehicles prior to the collision to come forward.
Anyone with information can contact Gloucestershire Constabulary through the website, quoting incident number 402 of 11 November: https://www.gloucestershire.police.uk/contact/af/contact-us/us/a-matter-involving-driving-vehicles-or-a-road-traffic-incident/