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Officers are appealing for witnesses to a fatal collision which happened near Aldsworth this afternoon, Friday 2 December.
Police were called to the B4425 at Riversmeet North shortly after 12.45pm with a report of a serious collision which involved multiple vehicles.
The collision, which took place between the Coln St Aldwyns and Eastington turnings, involved a grey Mini Cooper, black Audi A3, grey Polestar 2 and a black Seat Leon.
Emergency services attended and a man in his 50s from Cirencester was pronounced deceased at the scene. His next of kin has been informed.
Three people were taken to Southmead and John Radcliffe hospitals for treatment for serious injuries, and eight other people were taken to Gloucestershire Royal and Cheltenham General hospitals.
An 18-year-old woman has been arrested on suspicion of causing death by dangerous driving and taken to hospital as a precaution.
The B4425 and a number of surrounding roads remain closed while a collision investigation continues. Motorists are advised to find alternative routes.
Investigating officers would like to hear from anyone who has not already spoken to police and has information they feel may be relevant.
Anyone who has dashcam or CCTV footage which they believe would be relevant is also asked to make contact.
Information can be submitted to police online by completing the following form quoting incident 251 of 2 December: https://www.gloucestershire.police.uk/tua/tell-us-about/cor/tell-us-about-existing-case-report/