Police were called at 16.37 following a serious road traffic collision involving two cars at Kemble Enterprise Park, Cirencester. Ambulance and fire services also attended.
One man was declared dead at the scene. A second man and a woman were taken by ambulance to Southmead Hospital, Bristol - both suffering from serious injuries.
The A429 has been closed at the Coates junction.
Incident 321 of 14 November 2016 refers.
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